Stacked opioid exposure during preload and cross-taper.
During the preload and the cross-taper, you'll be on 7-OH (or MGM-15, MIT-A, pseudo) AND SR-17 at the same time. Keep naloxone (Narcan) on hand. Don't combine with alcohol, benzodiazepines, or other depressants. See the SR-17 page for full pharmacology and sourcing notes.
The SR protocol is the same shape for 7-OH, MGM-15, MIT-A, and pseudo. If you're on the synthetics (MGM-15 / MIT-A / pseudo) or stacking multiple compounds, extend the preload — these run longer in the body and the 1-day preload is calibrated for pure 7-OH.
Skip only if you've previously tested SR-17 from the same source and batch.
The community standard is 50 mg × 3 (every 6–8 h) for pure 7-OH. Some readers run higher per-dose totals early if 50 mg × 3 isn't holding them — raise SR, don't reach back for 7-OH.
Standard: 4 days at the preload total.
Final SR dose before stopping completely. Standard: 25 mg.
Day-by-day schedule
| Day | Phase | SR-17 | 7-OH | Notes |
|---|---|---|---|---|
| 0 | Allergy test | 10 mg × 1 | 15 mg × 3 = 45 mg/day | Take ~10 mg SR-17, wait several hours, watch for any reaction. 7-OH (or whatever synthetic you're on) stays at your normal dose. |
| 1 | Preload | 150 mg/day · 3 doses (~50 mg each) | 15 mg × 3 = 45 mg/day | Start SR-17 at full preload (50 mg every 6–8 h). 7-OH stays at the same dose. |
| 2 | Preload | 150 mg/day · 3 doses (~50 mg each) | 15 mg × 3 = 45 mg/day | |
| 3 | Preload | 150 mg/day · 3 doses (~50 mg each) | 15 mg × 3 = 45 mg/day | |
| 4 | Cross-taper | 150 mg/day · 3 doses (~50 mg each) | 8 mg × 3 = 23 mg/day | Cut 7-OH to 23 mg/day. |
| 5 | Cross-taper | 150 mg/day · 3 doses (~50 mg each) | — | Stop 7-OH. SR-17 carries you from here. |
| 6 | Hold | 150 mg/day · 3 doses (~50 mg each) | — | SR-17 only. Stable dose until the SR taper begins. |
| 7 | Hold | 150 mg/day · 3 doses (~50 mg each) | — | |
| 8 | Hold | 150 mg/day · 3 doses (~50 mg each) | — | |
| 9 | Hold | 150 mg/day · 3 doses (~50 mg each) | — | |
| 10 | SR taper | 100 mg/day · 2 doses (~50 mg each) | — | |
| 11 | SR taper | 75 mg/day · 2 doses (~38 mg each) | — | |
| 12 | SR taper | 50 mg × 1 | — | |
| 13 | Jump-off | 25 mg × 1 | — | Final SR-17 dose: 25 mg × 1. Stop after this dose. |
| 14 | Stop | — | — | Taper complete. |
The 7-OH doses on cross-taper days use the same per-day frequency you entered above.
"Copy schedule" puts the day-by-day plan on your clipboard as plain text. "Copy AI prompt" wraps it in scaffolding for an LLM to refine. "Save as PDF" opens a printable view in a new window.
SR-17 has never been studied in humans. All efficacy and safety data is rodent. The community protocol below is documented in detail on the SR-17 page; this calculator just does the day-by-day math from your inputs. SR-17 is still a mu-opioid agonist, it produces its own dependence and withdrawal, and the sourcing realities are real. Read the full page before committing to the protocol.
What this calculator builds
The SR-17 protocol is a cross-taper, not a single-substance taper. The calculator generates four sequential phases plus an optional allergy-test day:
- Phase 0 · Allergy test (~10 mg SR-17, wait several hours).
- Phase 1 · Preload. SR-17 ramps to full dose while 7-OH (or MGM-15 / MIT-A / pseudo) stays unchanged.
- Phase 2 · 7-OH cross-taper. 7-OH drops to zero — standard is cut-in-half then stop (2 days), custom is N equal cuts.
- Phase 3 · Hold. SR-17 only, at the preload total.
- Phase 4 · SR-17 taper down. SR steps down to your jump-off, then stop.
Defaults: a 3-day preload at 50 mg × 3 = 150 mg/day, standard cross-taper, 4-day hold, standard step-down (100 → 75 → 50 → 25 → jump). The SR-17 page documents the protocol with a 1-day preload as the textbook version; the calculator defaults to 3 days because most readers coming through here are on synthetics or stacks where the longer runway tends to work better. Drop it back to 1 for pure short-acting 7-OH, raise it further for harder cases.
When to extend the preload further
The 3-day default is the calculator’s middle-ground choice. Push it higher (4–5 days) if you’re stacking multiple compounds, coming off a high-dose pseudoindoxyl habit, or have a history of rough transitions where SR didn’t have enough time to settle before the 7-OH cuts started. Drop it back to 1 day if you’re on pure short-acting 7-OH and want the textbook-fast version on the SR-17 page.
What the calculator doesn’t do
- It doesn’t source SR-17 for you. The SR-17 page covers what to look for and avoid.
- It doesn’t decide whether SR-17 is the right path. Suboxone is the other community-validated path off the synthetics; the trade-offs are different.
- It doesn’t model interactions with alcohol, benzodiazepines, or other depressants. Don’t combine. Keep naloxone (Narcan) on hand throughout.
- It doesn’t replace community sense-checking. Bring your plan to the Discord before committing.
See also
- SR-17 — the full protocol page, pharmacology, sourcing, legal status
- Other taper calculators on this site
- Helper Medications — what to pair with the post-SR phase
- What is PAWS? — the post-SR tail